SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure
نویسندگان
چکیده
منابع مشابه
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1.
Sir2 (silent information regulator 2) is an NAD(+)-dependent histone deacetylase that contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones and various transcription factors, including p53, FOXO proteins, and peroxisome proliferator-activated receptor-gamma. We found that its subcellular localization varied in different tissues of the adult mouse. Some subse...
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NAD(+) plays central roles in energy metabolism as redox carrier. Recent research has identified important signalling functions of NAD(+) that involve its consumption. Although NAD(+) is synthesized mainly in the cytosol, nucleus and mitochondria, it has been detected also in vesicular and extracellular compartments. Three protein families that consume NAD(+) in signalling reactions have been c...
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The tumor suppressor p53 is a well-characterized regulator of energy metabolism. p53 transcriptionally regulates a number of major metabolic regulators such as 5′ AMP-activated protein kinase (AMPK) and regulators of AMPK including the sestrins, mTOR through TsC1/ TsC2, and glycolytic modulators such as TiGAR, hexokinase, and sCO2, which affect cellular oxidative stress.1 Moreover, p53 has 2 de...
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The mammalian cell contains a molecular clock that contributes, within each organism, to circadian rhythms and variety of physiological and metabolic processes. The clock machinery is constituted by interwined transcriptional-translational feedback loops that, through the action of specific transcription factors, modulate the expression of clock-controlled genes. These oscillations in gene expr...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2021
ISSN: 0021-9258
DOI: 10.1016/j.jbc.2021.100855